Ako ste na dugotrajnoj terapiji lekom Rivotril, možete postati zavisni od upotrebe ovog leka, a nagli prekid terapije može da izazove simptome obustave (videti poglavlje four).
Clonazepam exhibits pharmacological properties that happen to be popular to benzodiazepines and involve anticonvulsive, sedative, muscle relaxing and anxiolytic outcomes. The central steps of benzodiazepines are mediated by means of an improvement of the GABAergic neurotransmission at inhibitory synapses.
Administrarea concomitenta de inductori enzimatici, cum sunt barbituricele, hidantoinele sau carbamazepina poate accelera biotransformarea clonazepamului, fara a afecta legarea acestuia de proteinele plasmatice. Spre deosebire, clonazepamul nu pare sa aiba efect autoinductor enzimatic.
Starijim bolesnicima, bolesnicima s prethodnom bolešću respiratornog sustava (na pr. kroničnom opstruktivnom bolešću pluća), bubrega ili jetre, kao i bolesnicima koji se liječe lijekovima koji djeluju na središnji živčani sustav ili antikonvulzivnim (antiepileptičkim) sredstvima treba vrlo pažljivo prilagođavati dozu.
The physician who elects to make use of Rivotril for extended durations really should periodically reevaluate the very long-expression usefulness in the drug for the person client.
Ako bilo koje od ovih neželjenih dejstava postane ozbiljno ili zabrinjavajuće, ili ukoliko primetite neko
Cambios en el apetito: El Rivotril también puede afectar el apetito, lo que puede resultar en ganancia o pérdida de peso en algunos casos.
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In human it really is able to suppressing the spike and wave discharge in absence seizure (petit mal) and reducing the frequency, amplitude, duration and unfold of click here discharge in slight motor seizure.
Hypersekresjon fra spyttkjertler og bronkier hos spedbarn og småbarn; derfor spesielt viktig å opprettholde frie luftveier
Coma, if it does take place, ordinarily lasts a couple of several hours nonetheless it may become more protracted and cyclical, especially in elderly individuals. Enhanced frequency of seizures could arise in clients at supratherapeutic plasma concentrations. Benzodiazepine respiratory depressant outcomes tend to be more critical when compounded in sufferers with respiratory ailment.
Fenytoin induserer metabolismen av klonazepam by means of CYP3A4, klonazepam kan eventuelt hemme eller indusere metabolismen av fenytoin.
dacă aveţi ataxie spinală sau cerebrală (tremuraţi şi puteţi deveni nesigur pe picioare, aveţi
neželjenih reakcija možete da pomognete u proceni bezbednosti ovog leka. Sumnju na neželjene reakcije